GO:0036500 biological_process ATF6-mediated unfolded protein response
| PAG Title | GO:0036500 biological_process ATF6-mediated unfolded protein response |
| PAG ID | TAX023419 |
| Type | A |
| Source Link |  GOA |
| Publication Reference | NA |
| PAG Description | A series of molecular signals mediated by the endoplasmic reticulum membrane stress sensor ATF6 (activating transcription factor 6). Begins with activation of ATF6 in response to endoplasmic reticulum (ER) stress, and ends with regulation of a downstream cellular process, e.g. transcription. Under conditions of endoplasmic reticulum stress, ATF6 translocates to the Golgi where it is processed by proteases to release a cytoplasmic domain (ATF6f), which operates as a transcriptional activator of many genes required to restore folding capacity. |
| Species | Homo sapiens |
| Quality Metric Scores | nCoCo Score: 1,025 |
| Information Content | Rich |
| Other IDs | GO:0036500 |
| Base PAG ID | TAX023419 |
| Human Phenotyte Annotation | |
| Curator | PAGER curation team |
| Curator Contact | PAGER-contact@googlegroups.com |
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